Inhibition of regeneration restraining pathways to promote healing

Project Summary Abstract The long term objective of the proposed research is to enhance healing after injury that is often slow and incomplete. We hypothesized that injury to epithelial tissue like skin and gut share commonalities in healing, with some native injury responses which actually restrain healing. The goal of this grant is to define the mechanism of this restraint in hopes of developing therapies to enhance healing. We will test if inhibition of these pathways that restrain healing can improve regeneration after injury or infection to the gut or skin in the hopes of suggesting a new class of therapeutics to aid healing from diverse injuries.