ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERINGR01

Engineering Technologies for Acute Trauma Care

Active
Institution
University of Washington, WA
Principal investigator
Suzie H. Pun
Funding
$580K
Duration
2025–2029
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY Trauma-related injuries, such as from motor vehicle accidents, accidental falls or acts of violence, are the 3rd leading cause of death in the United States, and the leading cause of death for those between 1 and 46 years of age. Damage control resuscitation is initiated by first responders to restore tissue perfusion and oxygen delivery while preventing complications associated with aggressive resuscitation efforts. However, as most interventions for addressing bleeding rely on blood product transfusions, limited treatments are available for use outside the hospital setting. The goal of this proposal is to engineer novel, synthetic therapies for stabilizing trauma victims in the critical “golden hour” after injury. Our main objectives are to develop low volume resuscitants that provide fluid resuscitation while preserving the patient’s coagulation system and immune- modulating polymers that attenuate inflammation and neutralize reactive oxygen species. Successful completion of these aims will lead to new and critically-needed innovations for trauma medicine.

Research team

  • Suzie H. PunPI
  • Nathan J WhitePI

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERINGBiomaterials and Biointerfaces Study Section[BMBI]transfusionsaccidentalresuscitationtraumacause deathleading causetreatments availableoxygen

Questions for University of Washington

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.