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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESNIH · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESNIH
Epigenetic regulation of sporulation in Clostridioides difficile
Shen, Aimee (Contact)·TUFTS UNIVERSITY BOSTON, MA·2025–2026·ACTIVE
INSTITUTION
TUFTS UNIVERSITY BOSTON, MA
PRINCIPAL INVESTIGATOR
Shen, Aimee (Contact)
FUNDING
$261K
YEAR
2025
MOONBASE SCORE
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Abstract
Clostridioides difficile is a major nosocomial pathogen that costs the US healthcare system ~$5 billion to treat each year. Since the CamA DNA methyltransferase is important for infectious spore formation and persistence in mice, and CamA is unique to C. difficile, elucidating the impact of DNA methylation on C. difficile physiology could facilitate the development of new therapeutics.
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