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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Epigenetic regulation of sporulation in Clostridioides difficile

Active
Institution
TUFTS UNIVERSITY BOSTON, MA
Principal investigator
Aimee Shen
Funding
$261K
Duration
2025–2026
Open portfolio

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Abstract

Clostridioides difficile is a major nosocomial pathogen that costs the US healthcare system ~$5 billion to treat each year. Since the CamA DNA methyltransferase is important for infectious spore formation and persistence in mice, and CamA is unique to C. difficile, elucidating the impact of DNA methylation on C. difficile physiology could facilitate the development of new therapeutics.

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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR21Prokaryotic Cell and Molecular Biology Study Section[PCMB]methyltransferasesporeepigenetic regulationdifficileclostridioidesclostridioides difficilednanew therapeutics

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