ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISMR01

NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology

Active
Institution
Coriell Institute for Medical Research, NJ
Principal investigator
Xiaoxin Luke Chen
Funding
$579K
Duration
2022–2027
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY This multiple-PI R01 proposal is designed to incorporate both in vitro and in vivo approaches to elucidate the role of the NRF2-ACSS2 axis in alcohol-induced metabolic reprogramming and esophageal pathology. We hypothesize that the NRF2-ACSS2 axis mediates metabolic reprogramming in alcohol-associated esophageal pathology. We will test this hypothesis using human cells and genetically modified mice through three independent and complementary Specific Aims. In Aim 1, we will characterize the role of NRF2-ACSS2 axis in mediating alcohol-induced metabolic reprogramming in human esophageal squamous epithelial cells in vitro. In Aim 2, we will validate the role of the NRF2-ACSS2 axis in mediating alcohol-induced metabolic reprogramming in mouse esophagus in vivo. In Aim 3, we will examine the inhibitory effects of NRF2 and ACSS2 inhibitors on alcohol-induced metabolic reprogramming and esophageal pathology in vivo. If the hypothesis proved to be true, these studies will lay down a solid mechanistic foundation for NRF2/ACSS2 inhibition as a novel mechanism-based preventive measure against alcohol-associated esophageal pathology in the future.

Research team

  • Xiaoxin Luke ChenPI
  • Guofang ZhangPI

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISMXenobiotic and Nutrient Disposition and Action Study Section[XNDA]reprogrammingesophagealpathologymetabolicmetabolic reprogrammingalcohol-inducedaxisalcohol-associated

Questions for Coriell Institute for Medical Research

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.