ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL CANCER INSTITUTER01

A20 and Tumor Immune Responses

Active
Institution
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA
Principal investigator
Averil I Ma
Funding
$553K
Duration
2024–2029
Open portfolio

Moonbase score

Still being scored

Abstract

Abstract Immunosuppressive and homeostatic mechanisms prevent immune cells and tissues from eliminating solid tumors, limiting the efficacy of anti-tumor immunity. Precise dissection of these homeostatic mechanisms can lead to better understanding of how tumors persist and grow within tissues. Our prior studies demonstrate that the A20 protein is a potent regulator of immune homeostasis, regulating both pro-inflammatory and cell death signals. Our recent preliminary data reveal that A20 is highly expressed in tumor microenvironments and that one specific biochemical motif of this protein restrains both acute and anamnestic antitumor immunity. This proposal will dissect the cellular and molecular pathways by which A20 regulates anti-tumor immunity.

LOADING MOONBASE SCORE

R01NATIONAL CANCER INSTITUTETransplantation, Tolerance, and Tumor Immunology Study Section[TTT]homeostatictumorsimmunityantitumor immunityanti-tumor immunitymechanisms leadimmune homeostasisanti-tumor

Questions for UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.