Data Core RC2

PROJECT SUMMARY/ABSTRACT – Data Resource Core (RC2) The overall goal of RC2 is to enhance scientific productivity of investigators and projects supported by the UConn OAIC, and to external project investigators, by providing ready access to knowledge, expertise, and services related to study design, data capture, database management, data analysis, and measurement approaches. RC2 will support research relevant to Precision Gerontology in 4 functional domains, consistent with the theme of the UConn OAIC, and to independence of older persons. RC2 will offer individualized services as well as organized didactic and interactive learning opportunities, and in conjunction with other OAIC components will manage and provide access to a cross-study database with standardized measures for generation of new studies. RC2 will provide data-related support to 3 Pilot Studies in Year 1 as well as 2 Developmental Projects, including an RC2 Developmental Project featuring single cell RNAseq genomic profiling of PBMCs from metformin-flu vaccine biomarker data (in Year 1), and analyses linking biomarker data with physical function and frailty measures from one of the OAIC-supported pilot studies (PESC3; in Year 2).