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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF MENTAL HEALTH

Chemistry Core

Completed
Institution
Washington University, MO
Principal investigator
Douglas F Covey
Funding
$571K
Duration
2021–2026
Open portfolio

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Abstract

Abstract The center uses novel strategies to determine the mechanism(s) of action for the anti- depressant actions of neurosteroids. A panel of neurosteroid analogues with a range of previously determined mechanisms of action will be synthesized in the Chemistry Core for use in all Projects in the center. These include analogues with actions at NMDA receptors, GABAA receptors, Ca2+- channels, and intracellular targets. New tethered compounds will be synthesized to restrict actions to plasma-membrane channels. Existing and proposed photoaffinity labeling neurosteroids will be prepared in the core and used in Project 1 to identify novel sites. The core is a hub for evaluation of the impact of neurosteroids with varied cellular actions.

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NATIONAL INSTITUTE OF MENTAL HEALTHP50ZMH1-ERB-Gsynthesizedchannelstetheredgabaaanaloguesuses novelnmdaactions

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