Advanced Technology Core

ADVANCED TECHNOLOGY CORE (CORE C) PROJECT SUMMARY Leveraging the collective scientific expertise and resources across the DC CFAR partner institutions, the Advanced Technology Core (ATC) will provide an array of high impact laboratory services and training to HIV investigators in Washington, DC. Under the leadership of NIH-funded senior scientists and with a cadre of DC CFAR-supported Core service providers, the ATC will actively support high priority advanced technology services in virology, immunology, proteomics and bioinformatics, and provide access to other key laboratory services that utilize advanced technologies including single-cell analysis, -omics, specialized immunologic assays, CRISPR technologies, complex imaging, cryo-electron microscopy, machine learning, and HIV reservoir assays. The ATC will assist investigators in acquiring preliminary data for grant applications; conduct funded research protocols; and foster linkages with the Scientific Working Groups (SWGs) and Scientific Interest Groups (SIGs) and clinical and translational investigators. For Specific Aim 1, the ATC will provide high impact and advanced technology laboratory services (including single-cell analysis, omics, specialized immunology, CRISPR technologies, complex imaging, cryo-electron microscopy, machine learning, and HIV reservoir assays) to DC CFAR investigators. For Specific Aim 2, the ATC will facilitate service dissemination and training in advanced techniques and assays to recipients of Pilot, Transitioning Investigator, and NIH awards by organizing DC CFAR institutional workshops, the Core service laboratory “open house” series, and the annual Core Service Providers Research Day. For Specific Aim 3, the ATC will promote multidisciplinary forums by organizing workshops and seminars with the goal of connecting social, behavioral, clinical, and population scientists with the basic science investigators who are utilizing advanced technologies. These activities will contribute to addressing the DC CFAR mission of ending the HIV epidemic in Washington, DC and improving the health and quality of life of persons with HIV.