ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL CANCER INSTITUTE

Functional Genomics Shared Resource

Completed
Institution
COLD SPRING HARBOR LABORATORY, NY
Principal investigator
Christopher Vakoc
Funding
$151K
Duration
1997–2026
Open portfolio

Moonbase score

Still being scored

Abstract

FUNCTIONAL GENOMICS SHARED RESOURCE – PROJECT SUMMARY/ABSTRACT The Functional Genomics Shared Resource provides members of the Cold Spring Harbor Laboratory Cancer Center with access to advanced RNAi and CRISPR screening technologies and services. A major focus of this Shared Resource is to assist investigators with the design, implementation, and data analysis of multiplexed RNAi/CRISPR screens in mammalian cells. The Shared Resource has generated unique shRNA and CRISPR reagents that are not readily available elsewhere. These include a collection of verified domain-focused pooled CRISPR libraries and shRNA libraries targeted against gene families known to play key roles in cancer. In addition, the Shared Resource staff design and generate custom libraries based on Cancer Center member requests, and they collaborate with members to develop and optimize novel screening approaches. Expert training and assistance are provided to scientists at all stages of their functional genomics screening experiments. It is the goal of the Functional Genomics Shared Resource to leverage its innovative approaches to RNAi and genome editing to promote a deeper understanding of cancer pathways and dependencies, with the potential for discovery of new therapeutic targets and generation of disease-relevant models for improving human health. This Shared Resource is led by Faculty Head Christopher Vakoc, M.D., Ph.D., and Director Kenneth Chang, Ph.D. Over the last grant period, 22 Cancer Center members (58% of the membership) used the Functional Genomics Shared Resource, resulting in 32 publications.

LOADING MOONBASE SCORE

NATIONAL CANCER INSTITUTEP30Cancer Centers Study Section (A)[NCI-A]librariessharedcrisprgenomicsshared resourcefunctional genomicsshrnarnai

Questions for COLD SPRING HARBOR LABORATORY

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.