ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL HEART, LUNG, AND BLOOD INSTITUTE

The Role of ERBB4 in Atrial Electrophysiology and Atrial Fibrillation

Completed
Institution
NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY
Principal investigator
David S Park
Funding
$424K
Duration
2022–2026
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY Atrial fibrillation (AF) is the leading cause of stroke and a major cause of morbidity and mortality in the US. AF is due to both inherited and acquired factors. Genome-wide association studies have identified ERBB4 as a candidate susceptibility gene for AF. Acquired conditions, such as aging, hypertension, and heart failure, are known to cause electrical and structural changes in the left atrium (LA) in a process known as remodeling that predisposes to AF. Our data show that left atrial ERBB4 levels are reduced in patients with AF. We have also shown that ErbB4 is downregulated in heart disease mouse models. To study the role of ErbB4 in both atrial electrical development and in acquired AF mechanisms, we have generated mouse models that have reduced ErbB4 expression during development or acquired during adulthood. Both model systems show an important dependency of correct ErbB4 gene dosage in the maintenance of normal atrial electrophysiology.

LOADING MOONBASE SCORE

NATIONAL HEART, LUNG, AND BLOOD INSTITUTER01Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]electrophysiologyelectricalatrial fibrillationatrialreduced expressionacquiredleftfibrillation

Questions for NEW YORK UNIVERSITY SCHOOL OF MEDICINE

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.