Developing photoreceptor repair for macular degeneration therapy.
- Institution
- Johns Hopkins University, MD
- Principal investigator
- Mandeep Singh
- Funding
- $347K
- Duration
- 2021–2026
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Abstract
There is no available treatment for vision loss in dry age-related macular degeneration, a leading cause of blindness in adults over 55 years of age. Vision loss occurs when retinal pigment epithelium (RPE) and cone photoreceptors degenerate, so transplanting them is a potential treatment to restore vision. Using a novel mouse cone and RPE transplantation model system to study cone-RPE interactions in a regenerative paradigm, we will characterize donor cone maturation over the long term, reveal age-related impact on regeneration efficacy, and identify cues in specific recipient cell types that promote functional vision repair.
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