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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Core C: Human Tissue Validation

Completed
Institution
Icahn School of Medicine at Mount Sinai, NY
Principal investigator
Lea Tenenholz Grinberg
Funding
$116K
Duration
2021–2026
Open portfolio

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Abstract

PROJECT SUMMARY (CORE C: HUMAN TISSUE VALIDATION) The Human Tissue Validation Core will provide vital research support to the CWOW. Neurodegenerative disease pathology and genetics have become increasingly exciting and complex in recent years, with major advances arising from work accomplished using human postmortem tissue. In this application, Dr. Lea T. Grinberg will lead the Human Tissue Validation Core (Core C). The Human Core goals are to (1) directly supporting this CWOW’s Projects with well-characterized and carefully treated human tissue from tauopathy patients and controls; (2) validating the relevance results from Projects 1 and 2 in human specimens and assembloids; (3) developing enhanced tools for boosting the amount of information retrieved for each single biospecimen samples.

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NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEU54ZNS1-SRB-Shumanvalidationtissuetauopathyhuman tissueaccomplished usingsummary humanmajor advances

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