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NIHOFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

MHC Genetic Typing Core

Active
Institution
University of Washington, WA
Principal investigator
Charlotte Hotchkiss
Funding
$158K
Duration
2002–2028
Open portfolio

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Abstract

PROJECT SUMMARY - CORE 003 MHC GENETIC TYPING CORE Macaca nemestrina serves as a critical animal model for the study and treatment of AIDS and AIDS-related diseases. The MHC Genetic Typing Core ensures that MHC Class I alleles, lineages, and haplotypes are determined for all animals in the SPF breeding colony, using RNA expressed allele analysis. This information is provided to investigators to aid in animal selection and data analysis. In addition, parentage is confirmed for all animals using a 96 single nucleotide polymorphisms (SNP) panel developed specifically for M. nemestrina during the previous cycle of this cooperative agreement and fully implemented during the current cycle. We are initiating a project to generate whole genome sequences from representative colony animals to provide a foundation for identification of variations associated with specific phenotypes, both within the M. nemestrina population as well as among different macaque species.

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OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTHU42Special Emphasis Panel[ZRG1-EMS-H]haplotypescolonytypinganimalscurrent cyclespfmhcmhc class

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