Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research

Overall: Project Summary The Oregon National Primate Research Center's (ONPRC) expanded SPF (eSPF) Indian-origin rhesus macaque breeding colony was developed to support research focused on AIDS-defining opportunistic co- infections. The objective of this application is to maintain the ONPRC eSPF rhesus macaque breeding colony to produce well-characterized, Indian-origin rhesus macaques free of a broad number of enzootic and zoonotic agents that have the potential to confound research or pose a hazard to staff. The objective of this application is to request funds for continued support and maintenance of the eSPF Indian-origin rhesus monkey breeding colony. The specific aims address the components specified in the funding opportunity announcement and are divided into the Overall program, Husbandry and Management Core, Viral Testing Core, and MHC Genetic Typing Core. Program income and ONPRC funds will be used to support components of the program not covered by grant funds including per diem for colony animals in excess of the animals supported by this application, additional testing required for those animals, infrastructure repairs and improvements, veterinary clinical and pathology support, behavioral management support, and portions of genetic testing.