Functional Genomics and Bioinformatics Data management Core

FGBDMC ABSTRACT: The University of California, Irvine (UCI) MODEL-AD Functional Genomics and Bioinformatics Data Management Core (FGBDMC) will centralize all functional genomics as well as bioinformatics tasks to support the efforts of the UCI MODEL-AD Center. The core will characterize deeply UCI Late-Onset AD (LOAD) mouse models using bulk as well as single-cell techniques, and advise the UCI MODEL-AD Disease Model Development and Phenotyping Project (DMP) as to the best combination of variants and genetic backgrounds for subsequent models. Specifically, the FGBDMC will: 1) characterize novel mouse AD models using bulk RNA sequencing to identify model-specific changes in gene expression, 2) characterize selected mouse AD models using single-cell and single-nucleus RNA-seq and ATAC-seq to identify cell-type specific changes in gene expression and chromatin accessibility associated with AD GWAS risk-variant function, 3) analyze integratively all UCI MODEL-AD ‘omics data with AMP-AD and other publicly-available data in order to characterize the human AD relevance of the novel UCI mouse AD models as well as to predict the best variant combination to support DMP efforts, and 4) make UCI MODEL-AD results accessible on the Sage Bionetworks Synapse Portal.