Biostatistics Core

Core B (BIOSTATISTICS and BIOINFORMATICS CORE) – ABSTRACT The Biostatistics and Bioinformatics Core (Core B) provides statistical and bioinformatics collaboration and data management support for each of the three main projects, pilot projects, and the other cores in the Mayo Clinic Hepatobiliary Cancers (HBC) SPORE. Core B provides the HBC SPORE investigators with integrated access to the extensive infrastructure of the Mayo Clinic Comprehensive Cancer Center Biostatistics and Bioinformatics Core, methodological expertise in state-of-the-art human tumors and model systems (e.g., cell lines, patient- derived xenografts), multi-omics data analysis, clinical trial designs, cancer population studies, and cancer predictive modeling. Under the current HBC SPORE, Core B collaborative efforts for HBC SPORE projects have included the development of statistical design and analysis plans, quality control, database development and management, data pre-processing for bioinformatics workflows, computational genomics analyses, data analysis, integration, and interpretation, manuscript preparation, data archiving, and execution of data sharing plans. Through Core B, HBC SPORE investigators will continue to have direct access to a fully collaborative team of statistical/bioinformatics collaborators with content knowledge of HBCs. The resources of Core B ensure the development of study designs that address the questions posed using statistical and bioinformatics analysis techniques that are appropriate for the complex data generated in these diverse projects. In summary, Core B will continue to ensure that all analytic activities in the HBC SPORE are carried out in an efficient, effective, and rigorous manner.