Neuroregeneration after stroke using Vascular Guidance

Project summary This study addresses the challenge of improving neural progenitor (NP) survival and migration in the context of neurodegenerative diseases and brain injuries. It investigates the potential of adult CNS endothelial cells (ECs) to express developmental genes following epigenetic reprogramming, aiming to guide NP migration and enhance neurovascular communication. The research also delves into the capacity of CNS vessels, induced with developmental gene cohorts, to boost NP survival and migration in stroke-affected brains. Specific aims include comprehensive migration assays and the evaluation of post-stroke brain recovery through detailed assessments of NP survival, migration, and differentiation. The anticipated outcomes seek to contribute fundamental knowledge and potentially transform neural progenitor treatment strategies, proposing a novel approach that combines vascular rejuvenation with NP transplantation for improved cognitive and motor skills and overall enhanced clinical outcomes. If successful, the results of this application will significantly influence the design of neural progenitor (NP) transplant-treatment strategies for neurological disorders, including stroke.