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NOBEL PRIZE 2026

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NIHNATIONAL CANCER INSTITUTE

The ECOG-ACRIN SUPPORT Trial: Multilevel Intervention to Improve Diverse Enrollment in Cancer Clinical Trials

Active
Institution
ECOG-ACRIN MEDICAL RESEARCH FOUNDATION, PA
Principal investigator
Melissa A. Simon
Funding
$701K
Duration
2022–2028
Open portfolio

Moonbase score

Still being scored

Abstract

ABSTRACT National Cancer Institute (NCI) supported clinical trials (CTs) are key drivers of innovations in cancer care; however limited participation in NCI-supported CTs reduces reach and thus some are not able to fully benefit from cutting edge treatments and precision medicine. CT participation continues to fall short and the multitude of structural, clinical, physician, and patient barriers warrant multilevel interventions to enhance referral and enrollment to NCI-supported CTs. The ECOG-ACRIN Cancer Research Group (EA), as an NCORP Research Base, has engaged community providers and researchers through a robust research portfolio that spans Cancer Control, Cancer Prevention, and Cancer Care Delivery. We propose to leverage the collective resources of the EA, our team’s decades of work on improving participation in clinical trials, and our foundational work in patient navigation and CT research literacy tools to create and evaluate an ECOG-ACRIN Trial SUPPORT Toolkit (SUPPORT intervention) that aims to improve referral and enrollment in active NCI-supported therapeutic trials. The multilevel EA SUPPORT intervention consists of a CT research literacy tool and CT Resource Navigators who will interface with patients, providers, and community oncology site staff to improve referral and enrollment to CTs.

Research team

  • Elyse R. ParkPI
  • Melissa A. SimonPI

LOADING MOONBASE SCORE

NATIONAL CANCER INSTITUTEU01ZCA1-SRB-E(M2)literacycancerenrollmentcancer caresupport interventionctsreferralmultilevel

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