University of Wisconsin Prostate SPORE

PROJECT SUMMARY The University of Wisconsin (UW) Prostate Cancer SPORE is a highly collaborative research proposal that links basic scientists with prostate cancer clinicians to advance treatment strategies for prostate cancer patients. The broad objectives of this SPORE are to: 1) Increase multidisciplinary translational research and develop the next generation of prostate cancer researchers, 2) Develop common resources to promote advances, 3) Translate promising new approaches into patients, and 4) Improve overall survival and quality of life for patients with prostate cancer. A crosscutting theme that encompasses this SPORE is understanding tumor resistance in advanced prostate cancer and exploiting this knowledge to improve patient outcomes. The UW Prostate Cancer SPORE has three primary research projects: 1) Tumor Microenvironment Initiators of the Metastatic Cascade in High-Risk Prostate Cancer, 2) Androgen Deprivation as an Immune Modulating Therapy in Combination with Targeted Immunotherapy of Prostate Cancer, and 3) Extending Clinical Benefit by Selective Treatment of Resistant Lesions in mCRPC. The SPORE will support this research with three Cores (Administrative, Integrated Pathology Radiology, and Biostatistics and Bioinformatics). The Career Enhancement Program and Developmental Research Program will engage new and established investigators and further translational goals in a rich multidisciplinary environment. When completed, the research of the UW Prostate Cancer SPORE will advance our treatments and understanding of prostate cancer and undoubtedly beneficially impact patients with this disease.