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NOBEL PRIZE 2026

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NIHNATIONAL EYE INSTITUTER01

Transcriptional control of stress-induced resistance to retinal degeneration

Completed
Institution
UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA
Principal investigator
John D Ash
Funding
$326K
Duration
2021–2026
Open portfolio

Moonbase score

Still being scored

Abstract

Abstract: Retinal degenerations are a large cluster of diseases characterized by the irreversible loss of photoreceptors. The death of these cells results in a permanent loss of vision that can have debilitating impacts on an individual's quality of life. Despite the diversity among triggers for retinal degenerations, the mechanisms surrounding photoreceptor death are often similar, suggesting the possibility of developing gene/mutation-independent approaches to reduce blindness from multiple forms of retinal degeneration. We and others have shown that STAT3 is activated in all retinal cells, including photoreceptors and Müller cells during inherited retinal degeneration. Additional work has shown that activation of STAT3 plays an essential role in promoting a wide array of gene expression changes to increase the cell’s capacity to resist cell death. However, despite these impressive findings, little progress has been made in identifying the mechanisms by which STAT3 regulates protection. In this project, we will use state of the art techniques including single-cell RNA-seq and integrating the data with cell-specific ChIP-seq to comprehensively identify all genes and transcriptional networks regulated by STAT3 in retinal Müller cells and rods.

Research team

  • John D AshPI
  • Michael H ElliottPI

LOADING MOONBASE SCORE

R01NATIONAL EYE INSTITUTEBiology and Development of the Eye Study Section[BDE]deathdegenerationphotoreceptorsretinalretinal degenerationtranscriptional controlrodsapproaches reduce

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