Biostatistics and Bioinformatics Core

ABSTRACT The goal of the Biostatistics and Bioinformatics Core (BBC) is to collaborate with Phase 2 Center for Translational Viral Oncology (CTVO) investigators and other core scientists to enhance the quality of the research undertaken by the junior principal investigators and pilot project directors in the second phase of CTVO. The Core personnel have been selected because of their expertise in relevant areas of Biostatistics and Bioinformatics that are pertinent to CTVO projects and that foster teamwork in basic and translational research. The BBC will provide support in all stages of the study, beginning with the formulation of the research questions, experimental design, data collection, analysis, and interpretation, as well as writing of reports and dissemination of results. Core personnel have played a significant role in planning and data analyses for the proposed experimental plans in Phase 2 CTVO. The exact nature of the JPI/BBC collaboration will depend on the scientific emphasis and the project needs. In addition to direct support of the projects and other Cores, senior statisticians and bioinformaticians will also focus on the development of statistical methods and bioinformatics tools related to the needs of the projects in the CTVO. To achieve this goal, we will undertake the following Specific Aims: 1: Provide biostatistics and bioinformatics support on study design of clinical, laboratory and genomic studies and experiments for CTVO investigators; 2: Provide solutions and technology support services on data management and analyses to CTVO investigators, and 3: Develop novel biostatistics and bioinformatics methodology tools to address any issues that could not be addressed by existing methods. The ultimate goal is to provide custom-made and innovative biostatistics and bioinformatics support to successfully execute and complete the projects proposed in this Phase 2 CTVO grant renewal application.