Pathology and Biorepository Core (Core B)

SUMMARY: PATHOLOGY AND BIOREPOSITORY CORE (CORE B) The MD Anderson Brain Cancer SPORE operates in a deeply translational sense, progressing home-grown experimental treatment strategies to clinical trials to improve patient management. Given the paramount role of tissue and biomaterial analysis in this process, the Pathology and Biorepository Core has been a key driver of the success of this grant for many years. In this current proposal, the Core is ideally positioned to continue this service, having recently incorporated an innovative and near-comprehensive tissue procurement and processing pipeline. We pair these capabilities with unparalleled histopathological expertise and the wealth of experience gained over multiple funding cycles and through the support of numerous primary and developmental projects. For our Specific Aims, we will 1) Procure, bank, and supply relevant tissue and biomaterial to SPORE projects and the institutional brain tumor research community, 2) Coordinate clinical trial- associated tissue and biomaterial banking, processing, and databasing, 3) Support murine sample processing and higher-order human/murine tissue reagent development, 4) Provide histopathological, immunohistochemical, and molecular pathology expertise, and 5) Facilitate collaboration across the SPORE network.