Integrin-binding Peptide for Ocular Neovascularization and Macular Edema: Molecular Mechanism of Action
- Institution
- Johns Hopkins University, MD
- Principal investigator
- Peter A Campochiaro
- Funding
- $329K
- Duration
- 2019–2028
Moonbase score
Still being scored
Abstract
There is mounting evidence that integrins avl33 and a5131 play an important role in the stimulation of retinal/choroidal neovascularization (NV) and vascular leakage, but there are gaps in our knowledge of the mechanisms by which they act that this proposal seeks to clarify. A collagen IV-derived peptide mimetic that blocks avl33 and a5131 and exerts strong antiangiogenic and anti-permeability activity, AXT107, and newly developed analogs that have different but overlapping activities, will be used as tools to facilitate those mechanistic studies. In addition, suprachoroidal injection of AXT107 microparticles will be tested for sustained delivery and prolonged suppression of NV and vascular leakage to take advantage of the therapeutic potential of AXT107.
LOADING MOONBASE SCORE
Questions for Johns Hopkins University
Answered by the team behind this research.
No questions yet. Sign in to ask the first one
Related grants
Same researchers, same institution, same topic, scored first.
- NIH · Johns Hopkins UniversityNot yet scored
NAC Attack, A Phase-3, Multicenter, Randomized, Placebo-Controlled Trial in Patents with Retinitis Pigmentosa
Peter A Campochiaro · $302K · 2022–2027
- NIH · Johns Hopkins University72
Development, Piloting and Dissemination of an Integrated Clinical and Social Multi-level Decision Support Platform to Address Social Determinants of Health Among Minority Populations in Baltimore City
Elham Hatef-Naimi · $611K · 2021–2025
- NIH · Johns Hopkins University66
Glucose instability and neurocognitive outcomes in older adults
Elizabeth Selvin · $697K · 2021–2027