Core C: Biostatistics and Data Management

Biostatistics and Data Management Core: Project Summary The translational research projects proposed in this SPORE grant application integrate many different types of existing and newly generated data, including biological, clinical, demographic, genomic, metabolomic, lipidomic, molecular, social determinants of health, patient-reported outcomes, and survey and questionnaire data. The Biostatistics and Data Management Core (Core C) functions as a centralized research design and data science coordination center for all SPORE projects, bringing together expertise and intellectual resources in biostatistics, bioinformatics, geospatial data analysis, and data management for SPORE investigators. Core C members will 1) provide biostatistical and bioinformatics support for rigorous research design and stateof-the-art statistical analysis for all SPORE projects, 2) facilitate state-of-the-art geospatial data analysis for all SPORE projects, and 3) develop and maintain an integrated database environment for efficient data management, integration, analysis and sharing for all SPORE research projects, investigators, and participants. Core C members will work collaboratively with investigators to ensure that the appropriate design is incorporated into all studies from inception, that data are appropriately validated, linked, cleaned, and analyzed, and that all results will be interpreted for statistical as well as biological and clinical significance. The Biostatistics and Data Management Core will work with the Administrative Core (Core A) to assist in preparation of reports, data management and other administrative duties, with the Biospecimen Processing and Storage Core (Core B) for management and analysis of specimen-related data, and with Community Outreach and Engagement Core (Core D) for providing relevant community engagement documents. Fully integrating Core C members into all SPORE projects and other Cores will build workflow efficiencies and support the translational goals of the SPORE, while enhancing quality and ensuring scientific integrity of the participating projects. Core C will provide sophisticated data management, design, and analysis services in order to facilitate important discoveries about acute lymphoblastic leukemia disparities and to guide future prevention and intervention strategies.