Identification of Rare Variants for Orofacial Clefts Using Publicly Available Datasets
- Institution
- University of Iowa, IA
- Principal investigator
- Azeez Butali
- Funding
- $296K
- Duration
- 2025–2027
Moonbase score
Still being scored
Abstract
PROJECT SUMMARY Orofacial clefts (OFCs) are the most common birth defects affecting the head and neck. Families with OFCs face significant financial, educational, medical, psychological, and cultural challenges, including instances of infanticide due to stigmatization and a lack of sociocultural support. This proposal focuses on two key aims: (1) identifying craniofacial genes with rare non-synonymous deleterious variants, and (2) identifying craniofacial enhancers with rare deleterious variants. By identifying rare deleterious variants in craniofacial genes and enhancers, these aims will advance our understanding of the genetic and molecular mechanisms underlying oral clefts (OFCs), significantly contributing to the improvement of treatment, prevention, and overall quality of life for affected individuals and families.
LOADING MOONBASE SCORE
Questions for University of Iowa
Answered by the team behind this research.
No questions yet. Sign in to ask the first one
Related grants
Same institution, same topic, scored first.
- NIH · University of Iowa67
Airborne PCBs and Their Metabolites: Risk Factors for Adverse Neurodevelopmental Outcomes in Adolescence
Hans-Joachim Lehmler · $319K · 2006–2030
- NIH · University of Iowa66
Mitigating Airborne PCB Emissions from Sediments with Black Carbon Materials and PCB-Degrading Biofilms
Timothy E. Mattes · $306K · 2006–2030
- NIH · University of Iowa64
Platelet function abnormalities underlying bleeding in a connective tissue disorder the Ehlers Danlos syndrome
Anil Kumar Chauhan · $661K · 2025–2029