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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE ON AGINGR01

Mitochondria-Nuclear Communication via Lactylation in Alzheimer’s Disease

Active
Institution
UNIVERSITY OF KANSAS MEDICAL CENTER, KS
Principal investigator
Ning Wang
Funding
$556K
Duration
2025–2030
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY In response to RFA-AG-25-026, “Investigating Mitochondrial-Nuclear Communication in AD/ADRD,” we propose to investigate the overarching hypothesis that mitochondrial dysfunction in AD leads to increased glycolysis and elevated lactate production, which induces lactylation of histones and non-histone proteins. This post- translational modification (PTM), which conjugates lactyl groups to lysine residues on histones and proteins, results in structural and functional nuclear damage, epigenetic alterations, and dysregulation of gene expression in AD pathogenesis. We propose the following Specific Aims: 1) Investigate the effects of non-histone protein lactylation on nuclear structure and functions through tau. 2) Investigate epigenetic changes through histone lactylation in AD. 3) Characterize the effects of AD-patient-derived mitochondrial dysfunction in inducing both histone and non-histone protein lactylation through increased glycolysis. Upon completion, this study is expected to establish novel diagnostic and therapeutic targets against AD by focusing on lactylated histone and non- histone protein proteins, an area that has yet to receive NIH support.

Research team

  • Russell H. SwerdlowPI
  • Ning WangPI

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE ON AGINGSpecial Emphasis Panel[ZRG1 BN-A (50)]histonesglycolysismitochondrial dysfunctionnuclearstudy expectednih supportmitochondrialhistone

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