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NIHEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTR21

Defining the structure-interactome relationships of the basigin glycoprotein in endometriosis

Active
Institution
SCRIPPS RESEARCH INSTITUTE, THE, CA
Principal investigator
Mia L Huang
Funding
$506K
Duration
2025–2027
Open portfolio

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Abstract

Endometriosis is characterized by the extraneous presence of endometrial cells outside the uterine organ. The molecular mechanisms governing the migration of endometrial cells and the corresponding regulators of endometriosis are yet to be known, leaving critical gaps in the search for targets that can be used to treat endometriosis. We have recently found that an N-linked glycoprotein called basigin contributes to endometriosis. Here, we will apply proximity labeling technologies to define the interactome of basigin in cell culture models of endometriosis. Given the density of glycan post-translational modifications on basigin, we also reason that N-linked glycosylation can contribute to its interactome. The resulting interactomes will be used to define how basigin is regulating endometriosis and also open new potential targets for intervention.

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R21EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTChemical Biology and Probes Study Section[CBP]glycoproteinproximity labelinginteractomeendometriosisendometrialnew potentialtargets interventionused define

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