Resource and Service Section

PROJECT SUMMARY RESOURCE AND SERVICE CORE The overall goal of the Resource & Service Core is to publicize the mouse models and services developed through the JCPG and to distribute these models to the broader scientific community. To accomplish this goal, the Resources and Services Core will work closely with the Bioinformatics Core in the continuous development of the JCPG website for the dissemination of information related to the JCPG. The distribution of mice will leverage the existing mouse breeding, cryopreservation, biosecurity and quality assurance infrastructure at The Jackson Laboratory (JAX) as well as the existing NIH-funded Mutant Mouse Resource and Research Center (MMRRC) for a seamless transition of models from the core to the community. The Core will add new services and refine existing services to add to the existing fee for service program that operates in professional service environment, with customer quotes, project execution, deliverables, finalized reports and feedback. JAX has a 95-year history of developing, archiving, and distributing laboratory mice, and their derivative resources and information, to the scientific community. The JCPG will complement and expand resource stewardship at JAX by leveraging the deep expertise of JAX researchers and services. JAX is seeing a predictable demand for model generation services as a result of CRISPR/Cas9 genome editing technologies and the reduction in costs for patient sequencing. This, in turn, has increased the demand for phenotyping and ancillary services, such as behavioral assessments, histology, gene expression, proteomics, microscopy, etc. that can be tailored for each disease model. With the continuous advancement of gene-based therapies, the JCPG will help to satisfy the additional external need for pharmacology, safety and efficacy-based preclinical testing in mice. Operation of the JCPG Resource and Service Core will serve to: 1) Provide new mouse models to the scientific community, following well-established processes for rigor, quality assurance and customer service. Mice generated by the Disease Modeling Unit (DMU) will pass seamlessly through our customer service and production infrastructure to the JAX-MMRRC repository for maintenance, distribution and preservation. Each step of the process will be facilitated by tools and processes developed by the Bioinformatics section of the JCPG. 2) Refine existing and consider new key JAX services with input from our clients and make them available to the biomedical community on a fee-based mechanism with a focus on maximizing awareness and external availability using existing JAX outreach and marketing infrastructure and efforts. 3) Develop an integrated management and operational structure that weaves together core services and delivers them as efficiently as possible. Successful implementation of the Resource/Services core depends on our experienced management team to integrate individual service cores into a seamless program.