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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Molecular determinants of vaccine-induced antibody durability

Active
Institution
UNIVERSITY OF MARYLAND BALTIMORE, MD
Principal investigator
Mohammad Mohseni Sajadi
Funding
$777K
Duration
2025–2030
Open portfolio

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Abstract

This involves a clinical trial with vaccine-naïve volunteers using the licensed HPV vaccine, GARDASIL 9, for long-term responses, and an investigational HIV vaccine, GT1.1, for short-lived responses. Aim 1- A clinical trial will be carried out by vaccinating healthy volunteers intramuscularly with the HPV vaccine on the right thigh and GT1.1 on the left thigh, three times at 0, 1, and 6 months with scheduled collections of peripheral blood, lymph node fine needle aspirations (FNA), and bone marrow for 42 months to generate specimens spanning all phases of circulating antibody dynamics. Aim 2- The goal of Aim 2 is to quantify and characterize B cell responses the HPV capsid protein and gp120 epitopes in GT1.1 over the course of the clinical trial described above in the following specimens:

Research team

  • George K LewisPI
  • Mohammad Mohseni SajadiPI

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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESU01Special Emphasis Panel[ZAI1 VS-A (M1)]specimensantibodyvaccineclinical trialvolunteershiv vaccinehpv vaccinehpv

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