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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKER01

Direct and Indirect Neurogenesis in the Mammalian Neocortex

Active
Institution
BOSTON UNIVERSITY MEDICAL CAMPUS, MA
Principal investigator
Tarik F Haydar
Funding
$621K
Duration
2024–2029
Open portfolio

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Abstract

ABSTRACT The neocortex is the most complex cellular system in the natural world, the seat of motor, sensory and executive function. While many of the mechanisms responsible for neocortical formation have been discovered, key aspects of how neural precursor cells produce the exceptional variety of cortical neurons are unknown. Recent advances in genomic analysis and in vivo cellular labeling enable study of cortical development at an unprecedented level of resolution. Here we propose to operationalize our ability to label and track specific lineages of neurons, based on whether they were produced directly or indirectly from the apical radial glia stem cells, to determine how lineage information is used to construct the proper circuits in the developing neocortex. These studies will use emerging evidence and new tools to elucidate how neural precursor lineages influence neocortical growth.

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R01NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKENeurogenesis and Cell Fate Study Section[NCF]corticallineagescortical developmentneocortexprecursor cellsprecursorneocorticalenable study

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