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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites

Active
Institution
Wistar Institute, PA
Principal investigator
Daniel Kulp
Funding
$286K
Duration
2022–2027
Open portfolio

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Abstract

Project Summary The first project of our pan-CoV proposal is titled ‘Development of broad nanovaccines targeting diverse coronavirus receptor-binding sites’. Our team’s expertise will culminate in structurally guided coronavirus nanoparticle vaccines to broaden CoV vaccine protection. This proposal utilizes our novel platform to develop potent, RBS-focused nanoparticle vaccines to induce broad protection across CoV lineages, escape mutations and potential pandemic CoVs that are of concern. The project aims are: (1) Create a library of mutants that escape coronavirus immunity (2) Develop RBS-focused nanoparticle vaccines to induce broadly neutralizing antibodies to conserved sites using nucleic acid delivery and (3) Develop vaccine regimens to induce broad immunity and protection across diverse CoVs.

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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESP01ZAI1-JP-Winduceprotectionvaccinesescapevaccinecoronaviruscovnanoparticle

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