Dzip1 and Mitral Valve Prolapse

Project Summary Mitral valve prolapse (MVP) affects a significant portion of the population (1 in 40 individuals), yet its potential severity has been underestimated. Recent findings indicate that a substantial number of MVP patients develop left ventricular (LV) fibrosis, a serious complication. However, current surgical guidelines often delay intervention until patients exhibit symptoms of LV dysfunction, leading to poorer outcomes and increased mortality rates. Our research has unveiled MVP as a condition that impacts both the heart valve and the ventricle, highlighting the need for routine monitoring of LV function and consideration of cardioverter defibrillator implantation in MVP patients. This project aims to delve deeper into the mechanisms underlying MVP-related fibrosis. By investigating how MVP induces regionalized fibrosis, particularly in areas where tension forces are heightened, we aim to uncover the role of increased tension as a driver of LV fibrosis in MVP. This multidimensional approach will provide insights at the molecular, cellular, and tissue levels, contributing to a better understanding of MVP pathology.