Non-invasive Electrical Stimulation as a Therapy for Diabetic Keratopathy

Project Summary: This project focuses on exploring the effectiveness of non-invasive transpalpebral electrical stimulation (TpES) as a treatment for diabetic keratopathy (DK), a common complication in individuals with diabetes. DK results from nerve damage in the eye, leading to symptoms such as dryness, pain, and potential corneal injuries. Currently, the main treatment is a costly medication that can cause discomfort and requires frequent applications, making it hard for many patients to tolerate. The main objectives are to understand how TpES encourages the regeneration of corneal nerves and reduces painful sensations caused by nerve damage. By looking at the molecular processes involved, we hope to identify how this treatment not only helps the nerves grow back but also manages pain effectively. Methods will include assessing the structural and functional changes in corneal nerves following TpES application, as well as examining the underlying molecular mechanisms involved in nerve regeneration and pain modulation. The study will utilize behavioral analyses, molecular biology, and single cell imaging to gain insights into how TpES influences nerve recovery and reduces painful sensations. Ultimately, this research aims to establish TpES as a low-cost, effective treatment option for patients suffering from DK, enhancing their quality of life and addressing a significant unmet need in diabetic eye care. If successful, this treatment could change how we approach care for individuals with diabetic eye issues.