Grants.govNational Institutes of Health

Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)

Posted Jun 9, 2026·open

AGENCY

HHS-NIH11

PROGRAM

Discretionary

AMOUNT

—

CLOSES

Sep 25, 2028

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Description

The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus suppression in people who use substances and/or have a substance use disorder.

Eligibility

City or township governments; For profit organizations other than small businesses; Private institutions of higher education; Independent school districts; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Native American tribal governments (Federally recognized); Special district governments; Public and State controlled institutions of higher education; Small businesses; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments)

Contact

National Institutes of Health

nidagmbemail@nida.nih.gov

301-402-2541

Additional details

Funding instrument: Grant
Cost sharing required: No
Archived: Nov 24, 2028

Opportunity number: PAR-27-026

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