Grants.govNational Institutes of Health

GREGoRi Innovation Projects (U01 Clinical Trial Optional)

Posted Jun 18, 2026·open

AGENCY

HHS-NIH11

PROGRAM

Discretionary

AMOUNT

$3 – $500K

CLOSES

Oct 30, 2026

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Description

The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.

Eligibility

Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Independent school districts; Public and State controlled institutions of higher education; Private institutions of higher education; State governments; County governments; Public housing authorities/Indian housing authorities; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments; Native American tribal organizations (other than Federally recognized tribal governments); For profit organizations other than small businesses; Special district governments; Native American tribal governments (Federally recognized)

Contact

National Institutes of Health

nhgri-gregor@mail.nih.gov

301-402-2541

Additional details

Funding instrument: Cooperative Agreement
Cost sharing required: No
Archived: Dec 9, 2026

Opportunity number: RFA-HG-27-013

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