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NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

Posted Jun 29, 2026·open

AGENCY

HHS-NIH11

PROGRAM

Discretionary

AMOUNT

—

CLOSES

Sep 3, 2026

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Description

The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.

Eligibility

Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; State governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Private institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); City or township governments; Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; Independent school districts; Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments); Small businesses

Contact

National Institutes of Health

Transformative_Awards@mail.nih.gov

301-402-2541

Additional details

Funding instrument
Grant
Cost sharing required
No
Archived
Nov 2, 2026

Opportunity number: RFA-RM-27-003

Search this number on Grants.gov for the official listing.