Grants.govNational Institutes of Health

Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

Posted Jun 17, 2025·open

AGENCY

HHS-NIH11

PROGRAM

Discretionary

AMOUNT

—

CLOSES

Feb 17, 2028

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Description

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.

Eligibility

City or township governments; State governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; Native American tribal organizations (other than Federally recognized tribal governments); Private institutions of higher education; Public housing authorities/Indian housing authorities; Others (see text field entitled "Additional Information on Eligibility" for clarification); Independent school districts; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; County governments; For profit organizations other than small businesses; Public and State controlled institutions of higher education; Native American tribal governments (Federally recognized)

Contact

National Institutes of Health

grantsinfo@nih.gov

301-402-2541

Additional details

Funding instrument: Grant
Cost sharing required: No
Archived: Mar 24, 2028

Opportunity number: PAR-25-442

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