Grants.govNational Institutes of Health

NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

Posted Sep 22, 2025·open

AGENCY

HHS-NIH11

PROGRAM

Discretionary

AMOUNT

—

CLOSES

May 8, 2028

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Description

This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases at the molecular and cellular levels. This transformation will help move TOPMed from genetic Map to Mechanism with potential applications of AI and ML tool sets where possible, enabling functional genomics research that will accelerate mechanistic personalized medicine

Eligibility

For profit organizations other than small businesses; Private institutions of higher education; City or township governments; Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; State governments; Native American tribal governments (Federally recognized); Public housing authorities/Indian housing authorities; County governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; Public and State controlled institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); Independent school districts; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Contact

National Institutes of Health

grantsinfo@nih.gov

301-402-2541

Additional details

Funding instrument: Grant
Cost sharing required: No
Archived: Jun 13, 2028

Opportunity number: PAR-25-447

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