Grants.govNational Institutes of Health

Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)

Posted Jun 4, 2026·open

AGENCY

HHS-NIH11

PROGRAM

Discretionary

AMOUNT

Up to $500K

CLOSES

Jul 5, 2029

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Description

This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that individually, sequentially, or in combination trigger human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses also are encouraged.

Eligibility

Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; Public and State controlled institutions of higher education; For profit organizations other than small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments); City or township governments; County governments; Public housing authorities/Indian housing authorities; Private institutions of higher education; Small businesses; Special district governments; State governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education

Contact

National Institutes of Health

deeranotifications@nidcr.nih.gov

301-402-2541

Additional details

Funding instrument: Cooperative Agreement
Cost sharing required: No
Archived: Sep 3, 2029

Opportunity number: PAR-27-057

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