Grants.govNational Institutes of Health

NINDS Efficacy and Exploratory Clinical Trials (UG3/UH3 - Clinical Trial Required)

Posted Aug 31, 2026·open

AGENCY

HHS-NIH11

PROGRAM

Discretionary

AMOUNT

—

CLOSES

Mar 9, 2029

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Description

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated clinical trials to the National Institute of Neurological Disorders and Stroke (NINDS). These trials must address questions within the mission and research interests of the NINDS and may include studies of small molecules, biologics, devices as well as surgical, behavioral, diet-based, or rehabilitation therapies. Studies addressing neurological diseases and care across the lifespan are highly encouraged. This notice invites both early- and middle-phase exploratory clinical trials as well as later phase confirmatory Phase 3 or comparative effectiveness clinical trials.

Eligibility

State governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal organizations (other than Federally recognized tribal governments); Public housing authorities/Indian housing authorities; City or township governments; Small businesses; Public and State controlled institutions of higher education; Independent school districts; Special district governments; County governments; Native American tribal governments (Federally recognized); For profit organizations other than small businesses

Contact

National Institutes of Health

Exploratory_Efficacy_Trials@ninds.nih.gov

301-402-2541

Additional details

Funding instrument: Cooperative Agreement
Cost sharing required: No
Archived: May 8, 2029

Opportunity number: PAR-27-065

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