HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
AGENCY
HHS-NIH11
PROGRAM
Discretionary
AMOUNT
—
CLOSES
Oct 30, 2026
Description
The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.
Eligibility
Independent school districts; County governments; Special district governments; Public housing authorities/Indian housing authorities; Public and State controlled institutions of higher education; Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments); Private institutions of higher education; For profit organizations other than small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); City or township governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; State governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses
Contact
Additional details
- Funding instrument
- Grant
- Cost sharing required
- No
- Archived
- Dec 29, 2026
Opportunity number: PAR-27-045
Search this number on Grants.gov for the official listing.