Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)
AGENCY
HHS-NIH11
PROGRAM
Discretionary
AMOUNT
—
CLOSES
Oct 28, 2027
Description
The purpose of this notice of funding opportunity (NOFO) is to identify modifiable mechanisms and therapeutic targets to address central nervous system (CNS) complications associated with human immunodeficiency virus (HIV). The initiative supports a phased research approach beginning with the identification of patient phenotypes characterized by convergent pathophysiological features, followed by the discovery and experimental validation of molecular mechanisms using innovative in-vitro and in-vivo models. The goal of this NOFO is to advance therapeutic target, and intervention discovery to address the multifactorial and heterogeneous nature of HIV-associated CNS dysfunction.
Eligibility
Private institutions of higher education; State governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); County governments; Special district governments; Independent school districts; Native American tribal governments (Federally recognized); For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; City or township governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities
Contact
Additional details
- Funding instrument
- Grant
- Cost sharing required
- No
- Archived
- Dec 27, 2027
Opportunity number: RFA-MH-27-125
Search this number on Grants.gov for the official listing.