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Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)

Posted Oct 9, 2026·open

AGENCY

HHS-NIH11

PROGRAM

Discretionary

AMOUNT

—

CLOSES

Feb 8, 2027

Description

The National Institute on Drug Abuse (NIDA) invites applications to renew and expand the Collaboratory on Neural Ensembles and Used Substances (NExUS).

NExUS is a collaborative research program to decode how substance use experiences and addictive neurobehavioral states are represented in the brain at the level of cell populations. 

This funding opportunity seeks applications that propose systematic and scalable methods to identify, map, and analyze groups of neurons that respond to used substances. The goal is to create a comprehensive, multimodal database and use it to test hypotheses about how specific neural population activity patterns relate to behavioral states associated with substance use and substance use disorders (SUD), including intoxication, craving, and dependence.
 

Eligibility

Small businesses; Private institutions of higher education; Independent school districts; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; State governments; For profit organizations other than small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Special district governments; Native American tribal governments (Federally recognized); Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; City or township governments; County governments; Public housing authorities/Indian housing authorities

Contact

National Institutes of Health

INBranch_NIDA@nih.gov

301-402-2541

Additional details

Funding instrument
Cooperative Agreement
Cost sharing required
No
Archived
Apr 9, 2027

Opportunity number: RFA-DA-28-013

Search this number on Grants.gov for the official listing.