ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR01

Mapping the cell-type-specific molecular and genetic basis of lupus using single cell multiomics

Active
Institution
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA
Principal investigator
Chun Jimmie Ye
Funding
$783K
Duration
2024–2028
Open portfolio

Moonbase score

Still being scored

Abstract

Abstract Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with elevated prevalence in women and individuals of Asian, African, and Hispanic ancestries. SLE patients present a broad range of symptoms across multiple organ systems and differentially respond to treatments. Our central hypothesis is twofold: 1) genetic drivers of SLE affect gene regulatory mechanisms in specific cell types and activation states, and 2) cellular drivers responsible for disease initiation and exacerbation may exhibit transcriptional regulatory states (e.g., epigenomic states) poised to respond to environmental disease triggers. To test this hypothesis, we will use highly innovative multiplexed multimodal single-cell sequencing to map cell-type-specific epigenomic, transcriptomic, and surface protein features that stratify patients. When integrated with SLE GWAS data, we will further fine-map SLE-associated variants and annotate the cellular contexts by which associated variants act through. Finally, utilizing a novel strategy to sequence capillary blood, we will characterize circulating immune cells in SLE patients during flare, resolution, and response to discrete treatments. 3

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESGenetics of Health and Disease Study Section[GHD]lupusepigenomicrheumatic diseaseslecell-type-specificsle patientsflaredrivers

Questions for UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.