2025 Carotenoids Gordon Research Conference and Gordon Research Seminar

PROJECT SUMMARY The Carotenoids GRC is an international scientific conference focused on presentation of cutting-edge and unpublished research, scholarly discussion, and informal interactions among scientists of all career stages. Carotenoids are widespread isoprenoid pigments, vital for photosynthetic organisms and human health. In addition, they are the precursor of retinoids, such as vitamin A, and plant growth regulators and hormones involved in almost all aspects of plant life, including growth, development, stress response and communication with biotic environment. Animals obtain carotenoids through the diet and can accumulate, modify and convert them into retinoids and other bioactive apocarotenoids. Humans obtain carotenoids from red, orange, yellow, and dark green fruits and vegetables (F&Vs), seafood, dairy, and infants obtain carotenoids from human milk and some infant formula. Carotenoids confer anti-oxidant and anti-inflammatory activities associated with reduced risk of cancer and cardiovascular diseases. Vitamin A is critical for healthy growth, vision, and immune function. New evidence suggests roles of carotenoids in early neurodevelopment and metabolic health. Macular carotenoids confer retinal protection and improved visual function. The conference program emphasizes scientific, geographical, gender, racial, and cultural diversity more than any other carotenoid conference. The five-day conference is in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has poster sessions from individuals of all career stages, and afternoon free time and communal meals allow informal networking opportunities with leaders in the field. The conference emphasizes giving early career scientists the opportunity to present their work. The GRC will be preceded by the 5th edition of the Carotenoids Gordon Research Seminar (GRS), entirely organized by graduate students and postdocs, and enables them to present and discuss carotenoid research with their peers. Experienced mentors and trainee moderators facilitate active participation so that all attendees are engaged participants rather than spectators. Participants in the Carotenoids GRS have gone on to become major leaders in the carotenoid research field. The conference seeks to achieve the following aims: Aim 1. To promote cross-cutting discussion of the roles of carotenoids in human health, with an emphasis on children’s and maternal health, vision, cancer prevention, and cardiovascular disease prevention. Aim 2. To foster interdisciplinary discussion on progress in crop biofortification to address human vitamin A deficiency. Aim 3. To advance the careers of women, underrepresented groups, trainees, and early-career carotenoid scientists by creating an engaging and inclusive environment. Impact: This interdisciplinary carotenoid conference will fuel innovation and scientists to understand how carotenoids can support improved human health across the lifespan.