Myeloid Cells: Roles in Different Tissue Microenvironments

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: Roles in Different Tissue Microenvironments organized by Drs. Irina A. Udalova, Ana-Maria Lennon-Duménil and Paul Kubes, with scientific programming input from Keystone Symposia. The meeting will take place March 3–6, 2025 at Herrenhausen Palace, Hannover, Germany. Myeloid cells are essential components of the innate immune system and play a key role in the pathogenesis of many diseases. Myeloid cell roles are well characterized, but how myeloid cell responses are shaped by the local tissue microenvironment, including interaction with other cells, mechanical and osmotic influences, represents an important frontier area in the field. This meeting was designed to address the different mechanisms underlying signaling, epigenetic and metabolic adaptations of myeloid cells to their environments. The programmatic sessions aim to better integrate biochemical and biophysical concepts with more traditional immunological and genomic views of myeloid cells. The program will provide a forum for the sharing of new discoveries and the exchange of expertise, highlighting the latest tools, technical developments and resources that are available to study the diversity of myeloid states in various contexts. This meeting will bring together groups of scientists who normally would attend more specialized meetings and thus, will contribute to the growth of an interdisciplinary community focused on advancing the study of myeloid cell biology.