ANNOUNCEMENT

NOBEL PRIZE 2026

This year's laureates, their fields, and the discoveries that earned them the prize.Live nowSee the winners
Moonbase
← Back to Awards
NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESR01

Dissecting How Xenobiotics Act as Adjuvants for Oral Allergic Sensitization

Completed
Institution
Yale University, CT
Principal investigator
Andrew Wang
Funding
$575K
Duration
2021–2026
Open portfolio

Moonbase score

Still being scored

Abstract

PROJECT SUMMARY Food allergies have been increasing at an exponential rate since 1960 for unknown reasons. We hypothesized that modern xenobiotics that were widely introduced into the modern environment may be acting as allergic adjuvants to break oral tolerance and cause allergy. This proposal will explore how certain non-steroidal anti- inflammatory drugs (NSAIDs) are sufficient for oral allergic sensitization. The proposal will test the overarching hypothesis that adjuvant NSAIDs are activators of the xenobiotic sensor, Nuclear factor erythroid 2-related factor 2 (NRF2), in intestinal epithelial cells, which release IL33 to initiate the allergic response to coincident food antigen. We will use a combination of genetic, pharmacologic, and mass spectroscopic approaches to rigorously test this hypothesis. If confirmed, our work has major implications for why allergies are increasing and could lead to new public health policies and novel therapies for the management of allergic diseases.

LOADING MOONBASE SCORE

R01NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESSpecial Emphasis Panel[ZRG1-IDIB-E(57)]allergiessensitizationxenobioticadjuvantsallergic diseasesallergicoralhealth policies

Questions for Yale University

Answered by the team behind this research.

No questions yet. Sign in to ask the first one

Related grants

Same researchers, same institution, same topic, scored first.