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NOBEL PRIZE 2026

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NIHNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Principal Project-Characterization of ANA+ and ANA-B cells in individuals with SLE and healthy subjects

Active
Institution
FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY
Principal investigator
Betty Diamond
Funding
$335K
Duration
2019–2029
Open portfolio

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Abstract

Little is known about the differences between B cells reactive with nuclear antigen (ANA+) and ANA- B cells in individuals with systemic lupus erythematosus (SLE) or whether the regulation of ANA+ and ANA- B cells differs between SLE patients and healthy individuals. We will study activation and transcriptional profile in ANA+ and ANA- naïve, unswitched memory and switched memory B cells in individuals with active SLE, individuals with SLE in remission and healthy individuals. We will determine the antigenic and BCR repertoire of ANA+ B cells in these three cohorts to understand B cell selection. These studies are designed to reveal if there are aspects of ANA+ B cells in SLE that makes them susceptible to a therapeutic intervention that will not affect those B cells engaged in a protective response.

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NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESU19ZAI1-JTS-Ihealthyindividualsswitchedsleanasle patientspatients healthyhealthy individuals

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