Johns Hopkins Alzheimer's Disease Research Center

OVERALL – PROJECT SUMMARY/ ABSTRACT The responsibilities of Alzheimer’s Disease Centers (ADC) have expanded considerably over the last few years and now encompass not only basic and clinical research, but also training, community engagement, real-world translation, and public health. The Johns Hopkins Alzheimer’s Disease Research Center (JHADRC) is an integrated program of investigators whose overarching goal is to provide the infrastructure and resources to support innovative research and training in Alzheimer’s disease and related dementias (ADRD), and to contribute to city, state and national programs and collaborative activities with other ADCs. The particular scientific focus of the JHADRC is on the earliest stages of Alzheimer’s disease (AD) and related disorders in humans and in model systems, through characterizing the earliest clinical and pathophysiological processes, and by identifying cellular and molecular events that contribute to the abnormalities in model systems that capture aspects of the human disorders. Given the breadth of activities within our Center, many researchers also focus efforts on improving care of patients in the symptomatic phases of AD. With this application, the JHADRC is expanding the number of cores in the Center and will include 8 Cores and one component: (1) the Administrative Core (Core A), (2) the Clinical Core (Core B), (3) the Data Management and Statistics Core (Core C), (4) the Neuropathology Core (Core D), (5) the Outreach, Recruitment and Engagement Core (Core E), (6) the Neuroimaging Core (Core F), (7) the Biofluid Biomarker Core (Core G), (8) the iPSC Core and (9) the Research Education Component (REC). In this application we also include funds for 3 Developmental Projects.