Clinical and Translational Science Institute

Contact PD/PI: Collard, Harold R OVERALL ABSTRACT The University of California, San Francisco Clinical and Translational Science Institute (UCSF CTSI) has a long tradition and strong track record of building infrastructure, securing resources, and fostering and supporting a diverse, transdisciplinary workforce who share a vision and mission to accelerate research to improve health. In its second decade, CTSI now proposes a comprehensive plan to advance clinical and translational research nationally and at UCSF, with seven overall Specific Aims organized around the seven core themes of the CTSA network: Overall Aim 1. Theme: Methods and processes - Expand CTSI's network of regional partners to foster team science; improve regulatory efficiency and effectiveness in digital health-enabled research; implement more robust institutional oversight and stewardship of clinical trials; and strengthen support for translation of research to practice and policymakers. Overall Aim 2. Theme: Collaboration and engagement - Fully incorporate community stakeholders into clinical and translational research; promote and catalyze the translation of research into policy and clinical practice through the development of CTSI's new IMPACT Core; and expand CTSI's engagement with CTSA network initiatives. Overall Aim 3. Theme: Informatics - Enhance data interoperability across regional and national CTSA networks; expand informatics support for digital health research; and develop informatics competencies for the clinical and translational science workforce. Overall Aim 4. Theme: Integration across the lifespan - Increase integration of special populations into clinical and translational research; incentivize research across the lifespan through targeted subsidies to investigators; and collaborate with regional partners serving pediatric and rural populations. Overall Aim 5. Theme: Workforce development - Develop training programs in clinical informatics and data science; build skills in translating evidence to policy and practice; and collaborate across CTSA Hubs to enhance workforce development resources and opportunities for trainees. Overall Aim 6. Theme: Integration of health care and research - Expand CTSI's engagement in developing a learning health system and bolster CTSI's efforts to translate research into practice and policy by establishing an institutional home for evidence-to-practice and policy-based research; Overall Aim 7. Theme: Workforce heterogeneity - Actively develop underrepresented minority trainees through targeted initiatives and partner with the NIGMS-funded IDeA network to expand CTSI's rural health impact. These Overall Specific Aims describe a comprehensive strategy for training and sustaining the next generation of UCSF's clinical and translational workforce, with strategic goals that demonstrate CTSI's commitment to CTSA's core mission. Project Summary/Abstract Page 216 Contact PD/PI: Collard, Harold R